Allergies Atopies Cells Cytokines and JAK signaling.

IL4 IL5 IL13 TSLP IL33 immunogenicity immuneresponse immune Tcell Bcell antibodies CD4 CD8 immunology allergy education medicine JANUS jak1 anaphylaxis atopy atopicdermatitis asthma asthmatreatment abrilada eosinophilicesophagitis EoE esoninophil mastcell basophil histamine proteases Educational video: do you know that sometimes our immune system can react as an allergic response? I present here an explanation of the immune response characteristic of allergic and atopic diseases the cytokines and intracellular signaling and why JAK1 inhibitors are good therapies for some of these diseases. RECOMMENDED REFERENCES: YouTube Maria-Dolores Vazquez-Abad hypersensitivity responses: Type I hypersensitivity Antibody Response Th2 cells and B cells Th cells phenotypes Th1 Th2 and Th17 explained in 7 minutes in 5 min JAK1 in allergic and atopic responses IgE in less than 10 minutes Paul J Bryce PhD Allergies FOCIS advanced course of Immunology 2023 J. M. Igea. The history of the idea of allergy 2013 Allergy Aug688:966-73 Gell P.G.H. and Coombs R.R.A. 1963 Clinical Aspects of Immunology Allergy Asthma Proc . 2019 Nov 1406:470-473. doi: 10.2500aap.2019.40.4274 Front. Immunol. 07 June 2018 Sec. T Cell Biology Volume 9 - 2018 Front. Physiol. Sec. Clinical and Translational Physiology Volume 10 - 2019  Manning G Whyte DB Martinez R Hunter T Sudarsanan S. Science 2002298:1912-1934. Protein Kinases: Human Protein Kinases Overview Changelian P.S. Flanagan M.E. and Borie D.C. et al Science 2003 302 875 - 878. Flanagan M.E. and Changelian P.S. et al. J. Med. Chem. 2010 53 8468-8484. Flanagan M.E. Brown M.F. Subramanyam C. and Munchhof M.J. Ann. Rep. in Med. Chem. 2014 49 399-416 The Design of Covalent-Based Inhibitors Leonard Sung in Annual Reports in Medicinal Chemistry 2021 Clinical Immunology Sixth Edition 2023 Ferreira S Guttman-Yassky E Torres T. Selective JAK1 Inhibitors for the Treatment of Atopic Dermatitis: Focus on Upadacitinib and Abrocitinib. Am J Clin Dermatol. 2020 Dec216:783-798. doi: 10.1007s40257-020-00548-6. PMID: 32776305. J Allergy Clin Immunol. 2013 Oct 1324: 789788. doi: 10.1016j.jaci.2013.07.046,

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